We provide the first mapping of the critical surface in (2+1)-flavor QCD in the full $(T,μ_B,μ_Q,μ_S)$ space, anchored on lattice QCD results at vanishing chemical potentials and obtained within an expansion along contours of constant entropy density. In the pure $μ_B$ direction, this framework yields a critical point at $(T_c,μ_{B,c}) \simeq (114,, 602)$ MeV. Here we extend the construction to arbitrary directions in the three-dimensional chemical-potential space, parametrized by spherical coordinates $(μ,θ,φ)$, with the radial expansion truncated at $\mathcal{O}(μ^2)$. The resulting two-dimensional surface carries a direction-dependent critical temperature $T_c(θ,φ)$ and baryochemical potential $μ_{B,c}(θ,φ)$, which quantify the shift of the critical point relative to the pure $μ_B$ direction. We find that $μ_{B,c}$ increases by 40-100 MeV along the approximately strangeness neutral direction [$μ_S \approx (0.15$–$0.33), μ_B$, $μ_Q \approx 0$] relevant for heavy-ion collisions, while the critical temperature stays essentially unchanged. In the charge-neutral, weak-equilibrium direction~[$μ_Q \approx -(0.05$–$0.1) ,μ_B$, $μ_S = 0$] relevant for neutron star mergers, the critical point, and the associated first-order phase transition, remain present at essentially the same location in the $(T,μ_B)$ plane. We find no evidence for a critical point at large isospin densities, $|μ_Q| / μ_B \gtrsim 1$, relevant for cosmic trajectories in the early Universe, nor along the pure electric-charge or strangeness directions, at least outside the regions where pion or kaon condensation may occur.